Cyclo (Arg-Gly-Asp-D-Phe-Val)

Cyclo (Arg-Gly-Asp-D-Phe-Val) (Cyclo (RGDfV) ) is an integrin αvβ3 inhibitor. Cyclo (Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo (Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia[1].

Product Specifications

CAS Number

[137813-35-5]

Product Name Alternative

Cyclo (RGDfV) ; C (RGDfV)

UNSPSC

12352209

Target

Apoptosis; Integrin

Type

Peptides

Related Pathways

Apoptosis; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyclo-arg-gly-asp-d-phe-val.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](NC(CNC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC1=O)=O)=O)=O)CC(O)=O)N[C@@H]1CC2=CC=CC=C2

Molecular Formula

C26H38N8O7

Molecular Weight

574.63

References & Citations

[1]Shen ZH, et al. Targeting of the leukemia microenvironment by c (RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds. Oncol Lett. 2016 Nov;12 (5) :3278-3284.