Fluorogenic HDAC Substrate 2

<strong>Fluorogenic HDAC Substrate 2</strong>_x000D_ <strong>Catalog number:</strong> B2012841_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 250 nmol_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> HDAC, histone deacetylase_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Tan S, Li X. Small-Molecule Fluorescent Probes for Detecting HDAC Activity Chem Asian J. 2022 Nov 16;17(22):e202200835._x000D_ 2: Riester D, Wegener D, Hildmann C, Schwienhorst A. Members of the histone deacetylase superfamily differ in substrate specificity towards small synthetic substrates Biochem Biophys Res Commun. 2004 Nov 19;324(3):1116-23._x000D_ 3: Young Hong J, Cao J, Lin H. Fluorogenic Assays for the Defatty-Acylase Activity of Sirtuins Methods Mol Biol. 2019;2009:129-136._x000D_ 4: Riester D, Hildmann C, Grünewald S, Beckers T, Schwienhorst A. Factors affecting the substrate specificity of histone deacetylases Biochem Biophys Res Commun. 2007 Jun 1;357(2):439-45._x000D_ 5: Wegener D, Hildmann C, Riester D, Schwienhorst A. Improved fluorogenic histone deacetylase assay for high-throughput-screening applications Anal Biochem. 2003 Oct 15;321(2):202-8._x000D_ 6: Wegener D, Wirsching F, Riester D, Schwienhorst A. A fluorogenic histone deacetylase assay well suited for high-throughput activity screening Chem Biol. 2003 Jan;10(1):61-8._x000D_ 7: Song YM, Kim YS, Kim D, Lee DS, Kwon HJ. Cloning, expression, and biochemical characterization of a new histone deacetylase-like protein from Thermus caldophilus GK24 Biochem Biophys Res Commun. 2007 Sep 14;361(1):55-61._x000D_ 8: Moreno-Yruela C, Olsen CA. High-throughput screening of histone deacetylases and determination of kinetic parameters using fluorogenic assays STAR Protoc. 2021 Feb 3;2(1):100313._x000D_ 9: Skarpidi E, Cao H, Heltweg B, White BF, Marhenke RL, Jung M, Stamatoyannopoulos G. Hydroxamide derivatives of short-chain fatty acids are potent inducers of human fetal globin gene expression Exp Hematol. 2003 Mar;31(3):197-203._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/17037985">10: Moreth K, Riester D, Hildmann C, Hempel R, Wegener D, Schober A, Schwienhorst A. An active site tyrosine residue is essential for amidohydrolase but not for esterase activity of a class 2 histone deacetylase-like bacterial enzyme Biochem J. 2007 Feb 1;401(3):659-65. </a>_x000D_ _x000D_ <strong>Products Related to Fluorogenic HDAC Substrate 2 can be found at</strong> <a href="https://moleculardepot.com/product-category/Substrates/"> Substrates</a>