JBSNF-000088
Product Specifications
UNSPSC Description
JBSNF-000088 (6-Methoxynicotinamide), a analog of nicotinamide (NA), is a potent and orally active Nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 1.8 µM, 2.8 µM, and 5.0 µM for human NNMT, monkey NNMT and mouse NNMT, respectively. JBSNF-000088 inhibits NNMT activity, reduces MNA levels and drives insulin sensitization, glucose modulation and body weight reduction in animal models of metabolic disease[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/jbsnf-000088.html
Purity
99.94
Solubility
DMSO : ≥ 100 mg/mL|H2O : 1 mg/mL (ultrasonic)
Smiles
O=C(N)C1=CC=C(OC)N=C1
Molecular Weight
152.153
References & Citations
[1]Kannt A, et al. A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep. 2018 Feb 26;8(1):3660.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112584/JBSNF-000088-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112584/JBSNF-000088-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
7150-23-4
Available Sizes
Curated Selection
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