IBR2
IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis[1][2].
Product Specifications
CAS Number
313526-24-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; RAD51
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IBR2.html
Purity
98.60
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=S(N1C(C2=CNC3=C2C=CC=C3)C4=C(C=CC=C4)C=C1)(CC5=CC=CC=C5)=O
Molecular Formula
C24H20N2O2S
Molecular Weight
400.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhu J, et al. Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors. Eur J Med Chem. 2015;96:196-208.|[2]Jiewen Zhu, et al. A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. EMBO Mol Med. 2013 Mar;5 (3) :353-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
FT300F2020A Pack of 400
Pack of 400 Filter Sheets For Prefiltration, 200X200 Mm
Sign In for Pricing
View Details MBS7270845-01 48 Well
Goat Dynein heavy chain 10, axonemal ELISA Kit
Sign In for Pricing
View Details MBS7270845-02 96 Well
Goat Dynein heavy chain 10, axonemal ELISA Kit
Sign In for Pricing
View Details MBS7270845-03 5x 96 Well
Goat Dynein heavy chain 10, axonemal ELISA Kit
Sign In for Pricing
View Details MBS7270845-04 10x 96 Well
Goat Dynein heavy chain 10, axonemal ELISA Kit
Sign In for Pricing
View Details