Sp-8-pCPT-cGMPS

Sp-8-pCPT-cGMPS is a potent cyclic guanosine monophosphate-gated channel agonist and a lipophilic activator of protein kinase G (types I α, I β, and II) and protein kinase A type II with excellent cell membrane permeability and phosphodiesterase stability. Sp-8-pCPT-cGMPS can be used to study the role of cGMP in neural plasticity and synaptic transmission[1].

Product Specifications

CAS Number

[160385-87-5]

UNSPSC

12352005

Target

PKA; PKG

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sp-8-pcpt-cgmps.html

Smiles

O[C@@H]1[C@H](O2)[C@@H](CO[P@@]2(S)=O)O[C@H]1N(C(SC3=CC=C(Cl)C=C3)=N4)C5=C4C(NC(N)=N5)=O

Molecular Formula

C16H15ClN5O6PS2

Molecular Weight

503.88

References & Citations

[1]Wei J Y, et al. Substituted cGMP analogs can act as selective agonists of the rod photoreceptor cGMP-gated cation channel[J]. journal of Molecular Neuroscience, 1998, 10: 53-64.