KU-0063794

KU-0063794 is a potent and specific mTOR inhibitor, inhibiting both the mTORC1 and mTORC2 complexes with IC50s of 10 nM.

Product Specifications

CAS Number

[938440-64-3]

UNSPSC

12352005

Hazard Statement

H301

Target

MTOR

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ku-0063794.html

Concentration

10mM

Purity

99.67

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

OCC1=CC(C2=CC=C3C(N=C(N=C3N4CCOCC4)N5C[C@@H](O[C@@H](C5)C)C)=N2)=CC=C1OC

Molecular Formula

C25H31N5O4

Molecular Weight

465.54

Precautions

H301

References & Citations

[1]Garcia-Martinez et al. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR) . Biochem.J. (2009) 421 29.|[2]Collak FK, et al. Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1.J Biol Chem. 2012 Jul 6;287 (28) :23698-709. E|[3]Haagensen EJ, et al. The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition. Br J Cancer. 2012 Apr 10;106 (8) :1386-94.