Oteseconazole

Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candida albicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes[1][2].

Product Specifications

CAS Number

[1340593-59-0]

Product Name Alternative

VT-1161

UNSPSC

12352005

Hazard Statement

H228, H315, H319

Target

Cytochrome P450; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/oteseconazole.html

Concentration

10mM

Purity

99.60

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

O[C@@](CN1C=NN=N1)(C(C=CC(F)=C2)=C2F)C(F)(C3=CC=C(C4=CC=C(OCC(F)(F)F)C=C4)C=N3)F

Molecular Formula

C23H16F7N5O2

Molecular Weight

527.39

Precautions

H228, H315, H319

References & Citations

[1]Warrilow AG, et al. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58 (12) :7121-7.|[2]Garvey EP, et al. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model. Antimicrob Agents Chemother. 2015 Apr;59 (4) :1992-7.