CP-547632
CP-547632 is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC50s of 11 nM and 9 nM, respectively. CP-547632 is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs) . CP-547632 has antitumor efficacy[1].
Product Specifications
CAS Number
252003-65-9
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
FGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CP-547632.html
Purity
99.94
Solubility
DMSO : 115 mg/mL
Smiles
O=C(NC1=C(C(N)=O)C(OCC2=C(F)C=C(Br)C=C2F)=NS1)NCCCCN3CCCC3
Molecular Formula
C20H24BrF2N5O3S
Molecular Weight
532.40
Precautions
H302, H315, H320, H335
References & Citations
[1]Beebe JS, et al. Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy. Cancer Res. 2003 Nov 1;63 (21) :7301-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
FGFR; VEGFR2/KDR/Flk-1
Available Sizes
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