CP-547632

CP-547632 is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC50s of 11 nM and 9 nM, respectively. CP-547632 is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs) . CP-547632 has antitumor efficacy[1].

Product Specifications

CAS Number

[252003-65-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H320, H335

Target

FGFR; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CP-547632.html

Purity

99.94

Solubility

DMSO : 115 mg/mL

Smiles

O=C(NC1=C(C(N)=O)C(OCC2=C(F)C=C(Br)C=C2F)=NS1)NCCCCN3CCCC3

Molecular Formula

C20H24BrF2N5O3S

Molecular Weight

532.40

Precautions

H302, H315, H320, H335

References & Citations

[1]Beebe JS, et al. Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy. Cancer Res. 2003 Nov 1;63 (21) :7301-9.