Phospho-BRK (Tyr447) Antibody

Phospho-BRK (Tyr447) Antibody detects endogenous levels of BRK only when phosphorylated at Tyr447.<br>Tissue Specificity: Epithelia-specific. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. Not expressed in breast or ovarian tissue but expressed in high percentage of breast and ovarian cancers. Also overexpressed in some metastatic melanomas, lymphomas, colon cancers, squamous cell carcinomas and prostate cancers. Also found in melanocytes. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 2 is present in prostate epithelial cell lines derived from normal prostate and prostate adenocarcinomas, as well as in a variety of cell lines.

[protein-tyrosine kinase 6 isoform 2; Protein-tyrosine kinase 6; protein-tyrosine kinase 6; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kinase BRK; PTK6 protein tyrosine kinase 6; protein tyrosine kinase 6; Breast tumor kinase; Tyrosine-protein kinase BRK]