Phospho-Lamin A/C (Ser22) Antibody
Product Specifications
Gene Name
[LMNA]
NCBI Gene ID
4000
Reactivity
Human, Mouse, Rat
Storage Conditions
Store at -20 degree C. Stable for 12 months from date of receipt.
Specificity
Phospho-Lamin A/C (Ser22) Antibody detects endogenous levels of Lamin A/C only when phosphorylated at Ser22.<br>Tissue Specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
Other Gene Names
[LMNA; LMNA; FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B; LMN1]
Short Name
[Lamin A/C]
Other Product Names
[lamin isoform D; Prelamin-A/C; lamin; 70 kDa lamin; prelamin-A/C; lamin A/C-like 1; renal carcinoma antigen NY-REN-32; lamin A/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32]
NCBI GI Number
383792150
NCBI Accession Number
NP_001244303.1
NCBI GB Accession Number
NM_001257374.1
Uniprot Accession Number
P02545
CAS Number
9007-83-4
Available Sizes
Curated Selection
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