6,9,12,15,18-Heneicosapentaenoic acid

6,9,12,15,18-Heneicosapentaenoic acid (HPA; Heneicosapentaenoic acid methyl ester) inhibits the conversion of α-linoleic acid into Arachidonic acid (HY-109590) in hepatoma cells, the activation of prostaglandin H synthase and thromboxane synthesis in isolated platelets. 6,9,12,15,18-Heneicosapentaenoic acid is weak inducer of acyl-CoA oxidase in hepatoma cells[1].

Product Specifications

CAS Number

[65919-53-1]

Product Name Alternative

HPA; Heneicosapentaenoic acid methyl ester

UNSPSC

12352211

Hazard Statement

H225, H319

Target

PGE synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/6-9-12-15-18-heneicosapentaenoic-acid.html

Concentration

30.26 mM * 100 μL in Ethanol

Purity

99.4

Solubility

10 mM in DMSO

Smiles

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCC(OC)=O

Molecular Formula

C22H34O2

Molecular Weight

330.50

Precautions

H225, H319

References & Citations

[1]Larsen LN, et al., Heneicosapentaenoate (21:5n-3) : its incorporation into lipids and its effects on arachidonic acid and eicosanoid synthesis. Lipids. 1997 Jul;32 (7) :707-14.