Prunetin 5-O-β-D-glucopyranoside

Prunetin 5-O-β-D-glucopyranoside is an isoflavone isolated from extracts of Potentilla astracanica. Prunetin 5-O-β-D-glucopyranoside is a potent and uncompetitive inhibitor of α-glucosidase, with an IC50 of 56.05 μg/mL. Prunetin 5-O-β-D-glucopyranoside can be used for the research of type-2 diabetes[1].

Product Specifications

CAS Number

[89595-66-4]

UNSPSC

12352005

Hazard Statement

H315-H319

Target

Glycosidase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/prunetin-5-o-β-d-glucopyranoside.html

Solubility

10 mM in DMSO

Smiles

O=C1C(C2=CC=C(O)C=C2)=COC3=CC(OC)=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=C13

Molecular Formula

C22H22O10

Molecular Weight

446.40

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364

References & Citations

[1]Şöhretoğlu D, et, al. α-Glucosidase inhibitory effect of Potentilla astracanica and some isoflavones: Inhibition kinetics and mechanistic insights through in vitro and in silico studies. Int J Biol Macromol. 2017 Dec; 105 (Pt 1) :1062-1070.