Syntelin

Syntelin is a selective centromere protein E (CENP-E) inhibitor with IC50 at 160 nM. Syntelin has antitumor activity[1][2].

Product Specifications

CAS Number

[438481-33-5]

UNSPSC

12352005

Target

Kinesin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/syntelin.html

Purity

98.25

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(CSC1=NN=C(N1C2=CC=CC=C2)CSC3=NC(N)=C4C5=C(SC4=N3)CCCC5)O

Molecular Formula

C21H20N6O2S3

Molecular Weight

484.62

References & Citations

[1]Xue biao Yao, et al. Small molecule inhibitor syntelin against kinetochore motor protein cenp-e and use thereof. WO2012062044A1. 2012-05-18.|[2]Mullen M, et al. Syntelin inhibits triple-negative breast cancer cell proliferation and metastasis. J Mol Cell Biol. 2022 Jan 21;13 (11) :834-837.