MC-Val-Cit-PAB-Indibulin

MC-Val-Cit-PAB-Indibulin is a agent-linker conjugate for ADC with potent antitumor activity by using Indibulin (an orally applicable inhibitor of tubulin assembly), linked via the ADC linker MC-Val-Cit-PAB.

Product Specifications

CAS Number

[2055896-95-0]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mc-val-cit-pab-indibulin.html

Purity

95.82

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C2)=CC=C2C[N+]3=CC=C(C=C3)NC(C(C4=CN(CC5=CC=C(Cl)C=C5)C6=CC=CC=C46)=O)=O)=O)=O)=O

Molecular Formula

C50H55ClN9O8

Molecular Weight

945.48

References & Citations

[1]Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8 (12) :1112-1119.