PROTAC PRMT3 degrader 1

PROTAC PRMT3 degrader 1 (compound 11) is a PROTAC degrader targeting PRMT3. PROTAC PRMT3 degrader 1 can inhibit the growth of acute leukemia cells[1].

Product Specifications

UNSPSC

12352005

Target

Histone Methyltransferase; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-prmt3-degrader-1.html

Smiles

O=C([C@@H]1NC2([C@]3([C@H]1C4=CC=CC(Cl)=C4F)C(NC5=C3C=CC(Cl)=C5)=O)CCCCC2)NCCCCCCCCNC(C6CN(C(CNC(NC7=CC8=C(C=NC=C8)C=C7)=O)=O)C6)=O

Molecular Formula

C47H53Cl2FN8O5

Molecular Weight

899.88

References & Citations

[1]Zou W, et al. Discovery of PRMT3 Degrader for the Treatment of Acute Leukemia. Adv Sci (Weinh) . 2024 Aug 9:e2405963.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PRMT3

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