6-Deoxyjacareubin
Product Specifications
UNSPSC Description
6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1].
Target Antigen
Reactive Oxygen Species
Type
Natural Products
Related Pathways
Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/6-deoxyjacareubin.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(OC3=C1C=CC=C3O)C=C4C(C=CC(C)(C)O4)=C2O
Molecular Weight
310.30
References & Citations
[1]Hoshino T, et al. 6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis. Neurosci Res. 2021 Feb;163:43-51.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N2707/6-Deoxyjacareubin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N2707/6-Deoxyjacareubin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
16265-56-8
Available Sizes
Curated Selection
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