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BpV (pic) (potassium hydrate)

BpV (pic) potassium hydrate is a PTEN inhibitor with IC50 31 nM. BpV (pic) potassium hydrate is also an insulin simulator that activates insulin receptor kinase in cultured liver cancer cells, stimulates adipogenesis in adipocytes, and inhibits the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors in rat hepatosomes[1][2].

Product Specifications

CAS Number

148556-27-8

UNSPSC

12352005

Hazard Statement

H315, H319

Target

PTEN

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/bpv-pic-potassium-hydrate.html

Purity

98.8

Solubility

10 mM in DMSO

Smiles

O=[V]123([O-][O-]2)([O-][O-]3)([V][V+])[N](C=CC=C4)=C4C([O-]1)=O.[K+].O.O.[K+]

Molecular Formula

C6H8K2NO9V3 2-

Molecular Weight

469.15

Precautions

H315, H319

References & Citations

[1]Schmid AC, et al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004 May 21;566 (1-3) :35-8.|[2]Posner BI, et al. Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. J Biol Chem. 1994 Feb 11;269 (6) :4596-604.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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