γ-Aminobutyric acid-d6

γ-Aminobutyric acid-d6 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors) [2].

Product Specifications

CAS Number

[70607-85-1]

Product Name Alternative

4-Aminobutyric acid-d6

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; GABA Receptor

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Purity

99.92

Solubility

10 mM in DMSO|H2O : 50mg/mL (ultrasonic)

Smiles

OC(C([2H])([2H])C([2H])([2H])C([2H])([2H])N)=O

Molecular Formula

C4H3D6NO2

Molecular Weight

109.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Chen S, et al. Effects of dietary gamma-aminobutyric acid supplementation on the intestinal functions in weaning piglets. Food Funct. 2019 Jan 2.|[3]Okada R, et al. Gamma-aminobutyric acid (GABA) -mediated neural connections in the Drosophila antennal lobe. J Comp Neurol. 2009 May 1;514 (1) :74-91.|[4]Watanabe M, et al. GABA and GABA receptors in the central nervous system and other organs. Int Rev Cytol. 2002;213:1-47.