Ulefnersen
Product Specifications
UNSPSC Description
Ulefnersen (ION363) is an Antisense Oligonucleotide (ASO) directed against the 6th intron of the fused-in sarcoma (FUS) transcript to silence FUS in a non-allele-specific manner. Ulefnersen can reduce postnatal levels of FUS protein in the brain and spinal cord in disease-relevant mouse model of ALS-FUS , delaying motor neuron degeneration. Ulefnersen can be used in the research of Amyotrophic Lateral Sclerosis (ALS) [1].
Target Antigen
DNA/RNA Synthesis; Others
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage;Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ulefnersen.html
Solubility
10 mM in DMSO
Smiles
[Ulefnersen]
Molecular Weight
7059.72
References & Citations
[1]Korobeynikov VA, et al. Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis. Nat Med. 2022;28(1):104-116.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147410/Ulefnersen-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147410/Ulefnersen-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
2589926-25-8
Available Sizes
Curated Selection
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