Cibinetide

Cibinetide (ARA290) is an erythropoietin (EPO) derivative that acts as a specific agonist of the erythropoietin/CD131 heteroreceptor. ICibinetide can be used in the research of neurological disorders[1][2][3].

Product Specifications

CAS Number

[1208243-50-8]

Product Name Alternative

ARA290

UNSPSC

12352209

Target

Transmembrane Glycoprotein

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ARA290.html

Purity

99.23

Solubility

0.1 M NaOH : ≥ 50 mg/mL|DMSO : ≥ 34 mg/mL|H2O : 66.67 mg/mL (adjust pH to 8 with NH3·H2O)

Smiles

O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC1)NC1=O

Molecular Formula

C51H84N16O21

Molecular Weight

1257.31

References & Citations

[2]Carole Muller, et al. ARA290 Improves Insulin Release and Glucose Tolerance in Type 2 Diabetic Goto-Kakizaki Rats. Mol Med. 2015; 21 (1) : 969–978|[3]Chen H, et al. Therapeutic effects of nonerythropoietic erythropoietin analog ARA290 in experimental autoimmune encephalomyelitis rat. J Neuroimmunol. 2014 Mar 15;268 (1-2) :64-70|[1]Hache G, et al. ARA290, a Specific Agonist of Erythropoietin/CD131 Heteroreceptor, Improves Circulating Endothelial Progenitors' Angiogenic Potential and Homing Ability. Shock. 2016 Oct;46 (4) :390-7