123B9

123B9, a tumor-homing agent, is a potent and selective EphA2 agonist with a Kd value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors[1].

Product Specifications

CAS Number

[2225868-19-7]

UNSPSC

12352209

Target

Ephrin Receptor

Type

Peptides

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/123b9.html

Purity

99.67

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N3[C@@H](CCC3)C(N[C@@H](CCCC)C(N[C@@H](CCO)C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)NC(COC4=CC=C(C(Cl)=C4)F)=O

Molecular Formula

C58H82ClFN12O20

Molecular Weight

1321.79

References & Citations

[1]Bainan Wu, et al. Design and Characterization of Novel EphA2 Agonists for Targeted Delivery of Chemotherapy to Cancer Cells. Chem Biol. 2015 Jul 23;22 (7) :876-887.