Lu-AAZTA-NI-PSMA-093
Lu-AAZTA-NI-PSMA-093 enhances tumor uptake and retention by combining a hypoxia-sensitive nitroimidazole (NI) moiety with a targeting moiety to PSMA. Lu-AAZTA-NI-PSMA-093 can be used in prostate cancer[1].
Product Specifications
UNSPSC
12352211
Target
Radionuclide-Drug Conjugates (RDCs)
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lu-aazta-ni-psma-093.html
Smiles
O=C(O)CC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCCCNC([C@@H](NC(COC1=CC=C(C[C@H](NC(CNC(CC[C@H](NC(CCCCC2(N(CC(O3)=O)CC(O4)=O)C[N@]5(CC(O[Lu]6435OC(C7)=O)=O)CC[N@]67C2)=O)C(NCCCN8C=CN=C8[N+]([O-])=O)=O)=O)=O)C(O)=O)C=C1)=O)CC9=CC=CC=C9)=O)=O
Molecular Formula
C63H82LuN14O26
Molecular Weight
1626.37
References & Citations
[1]Luo Y, et al., 68Ga/177Lu-Labeled Bivalent Agents for Targeting Hypoxia and PSMA-Binding in Prostate Cancer. J Med Chem. 2024 Aug 8;67 (15) :13491-13506.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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