BAY 59-9435

BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC50 of 0.023 μM.

Product Specifications

CAS Number

[654059-21-9]

UNSPSC

12352005

Target

Lipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/HSL-IN-2.html

Purity

99.9200

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(C(C)C)=C(C)N(C(N2C[C@@H](C)CCC2)=O)O1

Molecular Formula

C14H22N2O3

Molecular Weight

266.34

References & Citations

[1]Ebdrup S, et al. Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase. J Med Chem. 2004 Jan 15;47 (2) :400-10.|[2]Elizabeth A Rondini, et al. Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown AdipocytesJ Pharmacol Exp Ther. 2017 Dec;363 (3) :367-376.|[3]Wenliang Zhang, et al. Adipocyte lipolysis-stimulated interleukin-6 production requires sphingosine kinase 1 activity. J Biol Chem. 2014 Nov 14;289 (46) :32178-85.