Anti-Caspase-13 Antibody

Rabbit Polyclonal Antibody specific to Caspase-13

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

CASP-13, EC 3.4.22.-, Evolutionary related interleukin-1-beta-converting enzyme, ERICE [Cleaved into: Caspase-13 subunit 1; Caspase-13 subunit 2]

Gene Name

CASP13

Gene ID

338039

NCBI Gene ID

UniProt

O75601

Accession Number

NP_788811.1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide corresponding to aa 91- 105 of human caspase-13 (accession no. O75601).

Target Antigen

Caspase-13

Target

Caspase-13

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB, IHC-P

Field of Research

Apoptosis

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.

Additionnal Information

Immunoblotting: use at 1ug/mL. Immunohistochemistry: use at 10ug/mL. These are recommended concentrations. Endusers should determine optimal concentrations for their applications. Positive control: Whole cell lysate from HL60 cells.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Specificity

This antibody recognizes human, mouse, and rat caspase-13 (43kDa).

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain-containing adapter molecules and members of the caspase family of proteases. Caspase-13 or ERICE (Evolutionarily Related Interleukin-1 Converting Enzyme) was recently described. When activated by caspase-8, caspase-13 induces apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.