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Ethylmalonic acid-d5

Ethylmalonic acid-d5 is the deuterium labeled Ethylmalonic acid. Ethylmalonic acid is a short-chain organic dicarboxylic acid. Ethylmalonic acid synergistically induces mitochondrial permeability transition (MP) with Ca2+, inhibits Mi-CK, and disrupts mitochondrial energy metabolism. Ethylmalonic acid can be used in the research of SCADD, EE and other genetic metabolic diseases characterized by EMA accumulation[1][2][3][4][5].

Product Specifications

CAS Number

66311-22-6

UNSPSC

12352211

Target

Isotope-Labeled Compounds; Mitochondrial Metabolism

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease; Neurological Disease

Purity

98.09

Solubility

10 mM in DMSO|DMSO : 250mg/mL (ultrasonic)

Smiles

O=C(O)C(C([2H])([2H])C([2H])([2H])[2H])C(O)=O

Molecular Formula

C5H3D5O4

Molecular Weight

137.15

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Cecatto C, et al. Ethylmalonic acid induces permeability transition in isolated brain mitochondria. Neurotox Res. 2014 Aug;26 (2) :168-78.|[3]Leipnitz G, et al. Ethylmalonic acid inhibits mitochondrial creatine kinase activity from cerebral cortex of young rats in vitro. Neurochem Res. 2003 May;28 (5) :771-7.|[4]Schuck PF, et al. Promotion of lipid and protein oxidative damage in rat brain by ethylmalonic acid. Neurochem Res. 2010 Feb;35 (2) :298-305.|[5]Schuck PF, et al. Brain and muscle redox imbalance elicited by acute ethylmalonic acid administration. PLoS One. 2015 May 26;10 (5) :e0126606.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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