Pamidronic acid (sodium)
Pamidronic acid sodium, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid sodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid sodium can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma[1][2][3][4].
Product Specifications
CAS Number
89131-02-2
UNSPSC
12352211
Target
RANKL/RANK ; Toll-like Receptor (TLR) ; Wnt; β-catenin
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pamidronic-acid-sodium.html
Smiles
O=P(O)(O[Na])C(O)(CCN)P(O)(O)=O
Molecular Formula
C3H10NNaO7P2
Molecular Weight
257.05
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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