Alternaphenol B2
Alternaphenol B2 is a selective IDH1 inhibitor from the coral-derived fungus Parengyodontium album SCSIO SX7W11. Alternaphenol B2 shows inhibitory activity against isocitrate dehydrogenase mutant R132H (IDH1m), with IC50 values of 41.9 μM[1].
Product Specifications
UNSPSC
12352005
Target
Isocitrate Dehydrogenase (IDH)
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alternaphenol-b2.html
Solubility
10 mM in DMSO
Smiles
OC1=C(C(C(OC2=C3C(O)=CC(CO)=C2)=O)=CC=C1)C3=O
Molecular Formula
C15H10O6
Molecular Weight
286.24
References & Citations
[1]Li X, Shen W, et al. Alternaphenol B2, a new IDH1 inhibitor from the coral-derived fungus Parengyodontium album SCSIO SX7W11 [published online ahead of print, 2023 Oct 18]. Nat Prod Res. 2023;1-7.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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