Amoxapine

Amoxapine (CL-67772) is a norepinephrine reuptake blocker and a 5-HT2/5-HT3 antagonist. Amoxapine can be used for the research of depression. Amoxapine has antibacterial activity. Amoxapine can enhance the killing effect of macrophages on mycobacterium by inducing autophagy, while protecting the cells from death[1][2][3].

Product Specifications

CAS Number

[14028-44-5]

Product Name Alternative

CL-67772

UNSPSC

12352005

Hazard Statement

H302

Target

Autophagy; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Autophagy

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Amoxapine.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 8.33 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(OC2=CC=CC=C2N=C3N4CCNCC4)C3=C1

Molecular Formula

C17H16ClN3O

Molecular Weight

313.79

Precautions

H302

References & Citations

[1]Wang J, et al. FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy. Microbiol Spectr. 2022 Oct 26;10 (5) :e0250922.|[2]Delgado C, Manzanares J, Tamargo J, Valenzuela C. Electrophysiological effects of amoxapine in untreated and in amoxapine-pretreated rat atria. Br J Pharmacol. 1986 Feb;87 (2) :317-25.|[3]Maudhuit C, et al. Effects of acute and chronic treatment with amoxapine and cericlamine on the sleep-wakefulness cycle in the rat. Neuropharmacology. 1994 Aug;33 (8) :1017-25.