SB 204741

SB 204741 is a selective and high affinity 5-HT2B antagonist with a pKi value of 7.1[1].

Product Specifications

CAS Number

[152239-46-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sb-204741.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC(C)=NS1)NC2=CC3=C(N(C)C=C3)C=C2

Molecular Formula

C14H14N4OS

Molecular Weight

286.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Bonhaus DW, et al. The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. Br J Pharmacol. 1995;115 (4) :622-628.|[2]Bharti S, et al. 5-HT2B receptor blockade attenuates β-adrenergic receptor-stimulated myocardial remodeling in rats via inhibiting apoptosis: role of MAPKs and HSPs. Apoptosis. 2015;20 (4) :455-465.