CHK1-IN-3
CHK1-IN-3 is a potent and selective CHK1 inhibitor with an IC50 of 0.4 nM. CHK1-IN-3 effectively inhibits the growth of malignant hematopathy cell lines and displays low affinity for hERG (IC50 > 40 μM) . CHK1-IN-3 significantly suppresses the tumor growth in vivo. CHK1-IN-3 can be used for the study of hematologic malignancies[1].
Product Specifications
CAS Number
2097252-39-4
UNSPSC
12352005
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/chk1-in-3.html
Purity
99.79
Solubility
DMSO : ≥ 125 mg/mL
Smiles
CNC1=C(C2=CN(C)N=C2)C=NC(NC3=CN=C(C#N)C(O[C@H]4CNCCC4)=C3)=N1
Molecular Formula
C20H23N9O
Molecular Weight
405.46
References & Citations
[1]Tong L, et al. Discovery of (R) -5- ((5- (1-methyl-1H-pyrazol-4-yl) -4- (methylamino) pyrimidin-2-yl) amino) -3- (piperidin-3-yloxy) picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies. Eur J Med Chem. 2019 Jul 1;173:44-62.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1
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Frequently Asked Questions
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