CHK1-IN-3

CHK1-IN-3 is a potent and selective CHK1 inhibitor with an IC50 of 0.4 nM. CHK1-IN-3 effectively inhibits the growth of malignant hematopathy cell lines and displays low affinity for hERG (IC50 > 40 μM) . CHK1-IN-3 significantly suppresses the tumor growth in vivo. CHK1-IN-3 can be used for the study of hematologic malignancies[1].

Product Specifications

CAS Number

[2097252-39-4]

UNSPSC

12352005

Target

Checkpoint Kinase (Chk)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/chk1-in-3.html

Purity

99.79

Solubility

DMSO : ≥ 125 mg/mL

Smiles

CNC1=C(C2=CN(C)N=C2)C=NC(NC3=CN=C(C#N)C(O[C@H]4CNCCC4)=C3)=N1

Molecular Formula

C20H23N9O

Molecular Weight

405.46

References & Citations

[1]Tong L, et al. Discovery of (R) -5- ((5- (1-methyl-1H-pyrazol-4-yl) -4- (methylamino) pyrimidin-2-yl) amino) -3- (piperidin-3-yloxy) picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies. Eur J Med Chem. 2019 Jul 1;173:44-62.