Recombinant Beta Catenin Antibody
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. [RefSeq]
Product Specifications
UniProt
P35222
Reactivity
Human, Mouse, Rat
Immunogen
Chicken beta Catenin protein was used as the immunogen for the recombinant beta Catenin antibody.
Clonality
Recombinant
Clone
RCTNNB1/2173
Conjugation
Unconjugated
Field of Research
Epigenetics, Infectious Diseases, Neuroscience, Signaling Pathways, Wnt
Purification
Protein G affinity chromatography
Dilution
Immunofluorescence: 1-3ug/ml, Western blot: 2-4ug/ml, Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Tested Applications
IF, IHC-P, WB
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG1, kappa
Available Sizes
Frequently Asked Questions
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