Levocetirizine

Levocetirizine ((R) -Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S) -Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1].

Product Specifications

CAS Number

[130018-77-8]

Product Name Alternative

(R) -Cetirizine

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/r-cetirizine.html

Purity

99.48

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)COCCN1CCN([C@@H](C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1

Molecular Formula

C21H25ClN2O3

Molecular Weight

388.89

Precautions

H302, H312, H332

References & Citations

[1]Lohar P, et al. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats. Biomed Chromatogr. 2019 Dec;33 (12) :e4672.