TLR7/8 agonist 1

TLR7/8 agonist 1 is a toll-like receptor (TLR7) /TLR8 dual-agonistic imidazoquinoline.

Product Specifications

CAS Number

[1258457-59-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tlr7-8-agonist-1.html

Purity

98.42

Solubility

DMSO : 11.11 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3CC4=CC=C(CN)C=C4

Molecular Formula

C22H25N5

Molecular Weight

359.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Shukla NM, et al. Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorg Med Chem Lett. 2010 Nov 15;20 (22) :6384-6.|[2]Beesu M, et al. Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. J Med Chem. 2015 Oct 8;58 (19) :7833-49.