Indoline
Indoline is a derivative of Indole. Indoline can use as the basic structure for CD4 mimetic compounds (CD4mcs), which triggers conformational changes of the HIV-1 envelope glycoprotein (Env) in advance, and causes viral inactivation. Indoline binds to gp120. Indoline CD4mcs can inhibit HIV-1AD8 with an IC50 in the micromolar range[1].
Product Specifications
CAS Number
496-15-1
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
HIV
Type
Biochemical Assay Reagents
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/indoline.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : ≥ 200 mg/mL
Smiles
C12=C(NCC2)C=CC=C1
Molecular Formula
C8H9N
Molecular Weight
119.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Fritschi CJ, et al., Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity. Proc Natl Acad Sci U S A. 2023 Mar 28;120 (13) :e2222073120.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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