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Indoline

Indoline is a derivative of Indole (HY-W001132) . Indoline can use as the basic structure for CD4 mimetic compounds (CD4mcs), which triggers conformational changes of the HIV-1 envelope glycoprotein (Env) in advance, and causes viral inactivation. Indoline binds to gp120. Indoline CD4mcs can inhibit HIV-1AD8 with an IC50 in the micromolar range[1].

Product Specifications

CAS Number

[496-15-1]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

HIV

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/indoline.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : ≥ 200 mg/mL

Smiles

C12=C(NCC2)C=CC=C1

Molecular Formula

C8H9N

Molecular Weight

119.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Fritschi CJ, et al., Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity. Proc Natl Acad Sci U S A. 2023 Mar 28;120 (13) :e2222073120.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Biochemical Assay Reagents

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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