Human BCAT2 Protein

<strong>Human BCAT2 Protein</strong>_x000D_ <strong>Catalog number:</strong> B2011627_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 500 µg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> BCAT 2 protein, BCAT-2, BCT2 protein, BCAT 2, mitochondrial protein, BCAT-2 protein, PP18 protein, BCATM protein, BCAM protein, Branched chain amino-acid aminotransferase 2 protein, BCAT2_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Wang K, Zhang Z, Tsai HI, Liu Y, Gao J, Wang M, Song L, Cao X, Xu Z, Chen H, Gong A, Wang D, Cheng F, Zhu H. Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells Cell Death Differ. 2021 Apr;28(4):1222-1236._x000D_ 2: Li JT, Yin M, Wang D, Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG, Wang YP, Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY. BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma Nat Cell Biol. 2020 Feb;22(2):167-174._x000D_ 3: Zhang B, Chen Y, Shi X, Zhou M, Bao L, Hatanpaa KJ, Patel T, DeBerardinis RJ, Wang Y, Luo W. Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma Cell Mol Life Sci. 2021 Jan;78(1):195-206._x000D_ 4: Lei MZ, Li XX, Zhang Y, Li JT, Zhang F, Wang YP, Yin M, Qu J, Lei QY. Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth Signal Transduct Target Ther. 2020 May 29;5(1):70._x000D_ 5: Anderson LC, Håkansson M, Walse B, Nilsson CL. Intact Protein Analysis at 21 Tesla and X-Ray Crystallography Define Structural Differences in Single Amino Acid Variants of Human Mitochondrial Branched-Chain Amino Acid Aminotransferase 2 (BCAT2) J Am Soc Mass Spectrom. 2017 Sep;28(9):1796-1804._x000D_ 6: McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma Cell. 2018 Sep 20;175(1):101-116.e25._x000D_ 7: Mehaffey MR, Sanders JD, Holden DD, Nilsson CL, Brodbelt JS. Multistage Ultraviolet Photodissociation Mass Spectrometry To Characterize Single Amino Acid Variants of Human Mitochondrial BCAT2 Anal Chem. 2018 Aug 21;90(16):9904-9911._x000D_ 8: Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers Science. 2016 Sep 9;353(6304):1161-5._x000D_ 9: Falcone M, Maddocks ODK. The KRAS-BCAA-BCAT2 axis in PDAC development Nat Cell Biol. 2020 Feb;22(2):139-140._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/34511290">10: Vargas-Morales JM, Guizar-Heredia R, Méndez-García AL, Palacios-Gonzalez B, Schcolnik-Cabrera A, Granados O, López-Barradas AM, Vázquez-Manjarrez N, Medina-Vera I, Aguilar-López M, Tovar-Palacio C, Ordaz-Nava G, Rocha-Viggiano AK, Medina-Cerda E, Torres N, Ordovas JM, Tovar AR, Guevara-Cruz M, Noriega LG. Association of BCAT2 and BCKDH polymorphisms with clinical, anthropometric and biochemical parameters in young adults Nutr Metab Cardiovasc Dis. 2021 Oct 28;31(11):3210-3218. </a>_x000D_ _x000D_ <strong>Products Related to Human BCAT2 Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>