8-Hydroxyguanine (hydrochloride)

8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine hydrochloride induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine hydrochloride is a marker of DNA oxidative damage[1][2].

Product Specifications

CAS Number

[1246818-54-1]

Product Name Alternative

8-Oxoguanine (hydrochloride) ; 8-oxo-Gua (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/8-hydroxyguanine-hydrochloride.html

Smiles

O=C1NC(NC(N)=N2)=C(N1)C2=O.Cl

Molecular Formula

C5H6ClN5O2

Molecular Weight

203.59

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Spencer JP, et al., DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 1995 Oct 30;374 (2) :233-6.|[2]Zhang W, et al. Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells. Antioxidants (Basel) . 2023 Jun 19;12 (6) :1300.