8-Hydroxyguanine (hydrochloride)
Product Specifications
UNSPSC Description
8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine hydrochloride induces mutagenesis and leads to a transversion from G to T[1][2].
Target Antigen
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/8-hydroxyguanine-hydrochloride.html
Smiles
O=C1NC(NC(N)=N2)=C(N1)C2=O.Cl
Molecular Weight
203.59
References & Citations
[1]Spencer JP, et al., DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 1995 Oct 30;374(2):233-6.|[2]Cheng KC, et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. J Biol Chem. 1992 Jan 5;267(1):166-72.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113338A/8-Hydroxyguanine-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113338A/
Clinical Information
No Development Reported
CAS Number
1246818-54-1
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