Allo-aca
Product Specifications
UNSPSC Description
Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models[1][2].
Target Antigen
Neuropeptide Y Receptor; Others
Type
Peptides
Related Pathways
GPCR/G Protein;Neuronal Signaling;Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/allo-aca.html
Purity
99.94
Solubility
DMSO : 50 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NC1=CC(OC(C=C2CC(N)=O)=O)=C2C=C1)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](O)C)N
Molecular Weight
1074.19
References & Citations
[1]Otvos L Jr, et al. Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer. Eur J Cancer. 2011;47(10):1578-1584.|[2]Coroniti R, et al. Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models [published correction appears in Front Mol Biosci. 2016 Nov 18;3:75]. Front Mol Biosci. 2016;3:67. Published 2016 Oct 13.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P3212/Allo-aca-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P3212/Allo-aca-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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