Allo-aca

Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models[1][2].

Product Specifications

UNSPSC

12352209

Target

Neuropeptide Y Receptor; Others

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/allo-aca.html

Purity

99.82

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NC1=CC(OC(C=C2CC(N)=O)=O)=C2C=C1)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](O)C)N

Molecular Formula

C48H75N13O15

Molecular Weight

1074.19

References & Citations

[1]Otvos L Jr, et al. Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer. Eur J Cancer. 2011;47 (10) :1578-1584.|[2]Coroniti R, et al. Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models [published correction appears in Front Mol Biosci. 2016 Nov 18;3:75]. Front Mol Biosci. 2016;3:67. Published 2016 Oct 13.