Anti-MSH2 Antibody
Mouse Monoclonal Antibody specific to MSH2
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
hMSH2, MutS protein homolog 2
Gene Name
MSH2
NCBI Gene ID
<a href="https://www.ncbi.nlm.nih.gov/gene/?term=MSH2">MSH2</a>
UniProt
P43246
Cellular Locus
Nucleus, Chromosome
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human MSH2
Target Antigen
DNA mismatch repair protein Msh2
Target
MSH2
Clonality
Monoclonal
Isotype
IgG2b
Type
Antibody
Applications
IHC
Field of Research
Cancer research
Purification Method
Purified by immunoaffinity chromatography
Concentration
Lot Specific
Dilution
Dilute in PBS or medium that is identical to that used in the assay system.
Format
Purified
Form
Liquid
Buffer
Tris
Function
Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha rPubMed:10078208, PubMed:10660545, PubMed:15064730, PubMed:17611581, PubMed:21120944, PubMed:26300262, PubMed:9564049, PubMed:9822679, PubMed:9822680}.
Additionnal Information
<br><br>Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 6 for 10-30 minutes. STORAGE AND STABILITY
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
Human MSH2. Reactivity with other species has not been investigated.
Formulation
Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide.
Buffer pH
pH 7.3-7.7
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