Anti-MSH2 Antibody

Mouse Monoclonal Antibody specific to MSH2

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

hMSH2, MutS protein homolog 2

Gene Name

MSH2

NCBI Gene ID

UniProt

P43246

Cellular Locus

Nucleus, Chromosome

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human MSH2

Target Antigen

DNA mismatch repair protein Msh2

Target

MSH2

Clonality

Monoclonal

Isotype

IgG2b

Type

Antibody

Applications

IHC

Field of Research

Cancer research

Purification Method

Purified by immunoaffinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Tris

Function

Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha rPubMed:10078208, PubMed:10660545, PubMed:15064730, PubMed:17611581, PubMed:21120944, PubMed:26300262, PubMed:9564049, PubMed:9822679, PubMed:9822680}.

Additionnal Information

<br><br>Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 6 for 10-30 minutes. STORAGE AND STABILITY