Human AMY3R (CTR&RAMP3) (Luc) BHK 21 Reporter Cell Development Service
The AMYRs are heterodimeric G protein-coupled receptors (GPCRs) that consist of a core class B GPCR subunit, the calcitonin receptor (CTR), in complex with a receptor activity-modifying protein (RAMP) accessory subunit that confers increased amylin potency. CTR co-expression with RAMP1, −2, or −3, gives rise to three amylin receptor subtypes, AMY1R, AMY2R, and AMY3R, respectively. These are drug targets for diabetes and obesity.
Product Specifications
Background
The AMYRs are heterodimeric G protein-coupled receptors (GPCRs) that consist of a core class B GPCR subunit, the calcitonin receptor (CTR), in complex with a receptor activity-modifying protein (RAMP) accessory subunit that confers increased amylin potency. CTR co-expression with RAMP1, −2, or −3, gives rise to three amylin receptor subtypes, AMY1R, AMY2R, and AMY3R, respectively. These are drug targets for diabetes and obesity.
Host
BHK 21
Target
AMY3R (CTR&RAMP3)
Tag
Luc
Applications
• Screen for AMYR agonists that can bind and activate AMY3R.
Format
Liquid
Shipping Conditions
Dry ice
Storage Conditions
Frozen in liquid nitrogen
Package Size
1Vial*2
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/SCBHK-ATF231.pdf
Species
Human
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