D-myo-Inositol 1,4,5-trisphosphate (tripotassium)

D-myo-Inositol 1,4,5-trisphosphate tripotassium, a second messenger, elicits Ca2+ mobilization. D-myo-Inositol 1,4,5-trisphosphate tripotassium inhibits the binding of phosphoinositide-specific phospholipase C-delta 1 (PLC-delta 1) to bilayer membranes composed of phosphatidylcholine (PC) and phosphatidylinositol 4,5-bisphosphate (PIP2) [1].

Product Specifications

CAS Number

[141611-11-2]

Product Name Alternative

Inositol 1,4,5-trisphosphate (tripotassium) ; Ins (1,4,5) -P3 (tripotassium)

UNSPSC

12352211

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d-myo-inositol-1-4-5-trisphosphate-tripotassium.html

Purity

98.00

Solubility

H2O : 50 mg/mL (ultrasonic; warming)

Smiles

O[C@H]1[C@H]([C@@H]([C@H]([C@@H]([C@H]1O)OP(O)(O[K])=O)OP(O)(O[K])=O)O)OP(O)(O[K])=O

Molecular Formula

C6H12K3O15P3

Molecular Weight

534.37

References & Citations

[1]D M Gou, et al. D-myo-inositol 1,4,5-trisphosphate analogues as useful tools in biochemical studies of intracellular calcium mobilization. Bioorg Med Chem. 1994 Jan;2 (1) :7-13. |[2]M E Cifuentes, et al. D-myo-inositol 1,4,5-trisphosphate inhibits binding of phospholipase C-delta 1 to bilayer membranes. J Biol Chem. 1994 Jan 21;269 (3) :1945-8.