STAT3-IN-35
STAT3-IN-35 is a STAT3 inhibitor that binds to SH2 domain. STAT3-IN-35 inhibits the phosphorylation of STAT3 and possesses antiproliferative activities against triple-negative breast cancer (TNBC) cell lines. STAT3-IN-35 also has a toxicity and potent antitumor activity in a TNBC xenograft model[1].
Product Specifications
CAS Number
2849535-96-0
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-in-35.html
Smiles
O=C(C1=O)C2=CC=CC=C2C3=C1C4=C(O3)CN(CC4)[C@H](CO)CC(C)C
Molecular Formula
C21H23NO4
Molecular Weight
353.41
References & Citations
[1]Fan C, et al. Natural Product-Inspired Discovery of Naphthoquinone-Furo-Piperidine Derivatives as Novel STAT3 Inhibitors for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2024 Sep 12;67 (17) :15291-15310.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb3096712 100 µg
P2Y6/P2RY6 Rabbit Polyclonal Antibody (Fluoro647)
Sign In for Pricing
View Details