WIZ degrader 1
WIZ degrader 1 (Compound 141) is a degrader for widely interspaced zinc finger motifs (WIZ) with an AC50 of 2 nM. WIZ degrader 1 induces the expression of fetal hemoglobin (HbF) with an EC50 of 6 mM. WIZ degrader 1 is used in research of inherited blood disorders[1].
Product Specifications
CAS Number
2839552-68-8
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/wiz-degrader-1.html
Smiles
FC1(F)CCC(CN2CC[C@@H](CC3=CC4=C(N5CCC(NC5=O)=O)C=NN4C=C3)C[C@@H]2C)CC1
Molecular Formula
C25H33F2N5O2
Molecular Weight
473.56
References & Citations
[1]BONAZZI S, et al., Pyrazolopyridine Derivatives and Uses thereof. US20240158374A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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