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Anti-Thyroglobulin Mouse Monoclonal Antibody - Library Pack

Selection of Mouse Monoclonal antibodies specific to Thyroglobulin

Product Specifications

Product Name Alternative

Anti-Thyroglobulin Mouse Monoclonal Antibody Library Pack - Includes 100 ug of each of the following antibodies:<br><br> 12101 - Anti-Thyroglobulin Mouse Monoclonal Antibody - Clone TG60 - Isotype IgG1<br> 12102 - Anti-Thyroglobulin Mouse Monoclonal Antibody - Clone TG62 - Isotype IgG1<br> 12103 - Anti-Thyroglobulin Mouse Monoclonal Antibody - Clone TG8.1 - Isotype IgM<br> 12104 - Anti-Thyroglobulin Mouse Monoclonal Antibody - Clone TG9.1 - Isotype IgG1<br>

Gene Name

TG

Gene ID

188450

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=TG">TG</a>

UniProt

P01266

Cellular Locus

Secreted

Host

Mouse

Reactivity

Human

Immunogen

Purified human thyroglobulin.

Target Antigen

Thyroglobulin

Target

Thyroglobulin

Clonality

Monoclonal

Type

Antibody Library Pack

Applications

ELISA

Field of Research

Hormones/Proteins

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:32025030, PubMed:17532758). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030). {PubMed:17532758, PubMed:32025030}.

Additionnal Information

These antibodies may be used in ELISA to detect and quantitate thyroglobulin.

Storage Conditions

These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/12101-12104.pdf

Specificity

12102 is T4-specific and 12104 is T3-specific. 12101 and 12103 recognize both T3 and T4.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by the follicular cells of the thyroid. Thyroglobulin accounts for approximately half of the protein content of the thyroid gland. Human TG is a homodimer of subunits each containing 2768 amino acids as synthesized (a short signal peptide may be removed from the N-terminus in the mature protein). Tg is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3).

CAS Number

9007-83-4

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