2′-O- (2-Methoxyethyl) guanosine

2′-O- (2-Methoxyethyl) guanosine (2'-O-MOE-rG) is a 2'-O-methoxyethyl-modified nucleoside analogue and an important intermediate in the synthesis of nucleic acid drugs. 2′-O- (2-Methoxyethyl) guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA[1][2].

Product Specifications

CAS Number

[473278-54-5]

Product Name Alternative

2'-O-MOE-rG

UNSPSC

12352200

Hazard Statement

H302

Target

DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

Type

Biochemical Assay Reagents

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-o-2-methoxyethyl-guanosine.html

Concentration

10mM

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1[C@@H](OCCOC)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O[C@@H]1CO

Molecular Formula

C13H19N5O6

Molecular Weight

341.32

Precautions

H302

References & Citations

[1]McPherson AK, et, al. An Improved Process for the Manufacture of 5′-O- (4,4′-Dimethoxytrityl) -N2-isobutyryl-2′-O- (2-methoxyethyl) guanosine. Org. Process Res. Dev. 2020, 24, 11, 2583-2590.|[2]Saleh AF, et, al. 2'-O- (2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells. Toxicol Sci. 2018 May 1;163 (1) :70-78.