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Pemetrexed (disodium heptahydrate) (Standard)

Pemetrexed (disodium heptahydrate) (Standard) is the analytical standard of Pemetrexed (disodium heptahydrate) . This product is intended for research and analytical applications. Pemetrexed disodium heptahydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.

Product Specifications

CAS Number

357166-29-1

Product Name Alternative

LY231514 (disodium heptahydrate) (Standard)

UNSPSC

12352211

Target

Antifolate; Autophagy; Reference Standards

Type

Reference Standards

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pemetrexed-disodium-heptahydrate-standard.html

Smiles

O=C(O[Na])CC[C@@H](C(O[Na])=O)NC(C1=CC=C(CCC2=CNC(N=C(N)N3)=C2C3=O)C=C1)=O.[7H2O]

Molecular Formula

C20H19N5Na2O6.7H2O

Molecular Weight

597.48

References & Citations

[1]Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57 (6) :1116-23.|[2]Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185 (2) :956-66.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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