Chloramphenicol

Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research[1][2][3].

Product Specifications

CAS Number

[56-75-7]

UNSPSC

12352005

Hazard Statement

H318, H351, H361

Target

Akt; Antibiotic; Apoptosis; Autophagy; Bacterial; Beclin1; HIF/HIF Prolyl-Hydroxylase; JNK; MMP; VEGFR

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Chloramphenicol.html

Purity

99.96

Solubility

DMSO : ≥ 150 mg/mL|Ethanol : 100 mg/mL (ultrasonic) |H2O : 3.06 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1)C(Cl)Cl

Molecular Formula

C11H12Cl2N2O5

Molecular Weight

323.13

Precautions

H318, H351, H361

References & Citations

[1]Hsu HL, et al. Chloramphenicol Induces Autophagy and Inhibits the Hypoxia Inducible Factor-1 Alpha Pathway in Non-Small Cell Lung Cancer Cells. Int J Mol Sci. 2019 Jan 3;20 (1) :157. |[2]Yuan ZR, et al. Chloramphenicol induces abnormal differentiation and inhibits apoptosis in activated T cells. Cancer Res. 2008 Jun 15;68 (12) :4875-81. |[3]Li CH, et al. Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion. Toxicol Sci. 2010 Jul;116 (1) :140-50. |[4]Turton JA, et al. Characterization of the myelotoxicity of chloramphenicol succinate in the B6C3F1 mouse. Int J Exp Pathol. 2006 Apr;87 (2) :101-12. |[5]Bartlett JG. Chloramphenicol. Med Clin North Am. 1982;66 (1) :91-102.